PrenatalSafe® is a non-invasive prenatal test that analyzes circulating cell-free fetal DNA isolated from a maternal blood sample. The PrenatalSafe® Plus test detects aneuploidies of chromosomes 21, 18, 13, 9, 16 and sex chromosomes (X and Y), as well as including fetal sex determination (optional). It is also possible to detect the presence of 6 of the most common microdeletion syndromes:
Microdeletion syndrome
Chromosomal Region
Prevalence (at birth)
DiGeorge Syndrome
22q11.2 deletion
1/2.000 – 1/4.000
Cri-du-chat Syndrome
5p deletion
1/15.000 – 1/50.000
Prader-Willi Syndrome
15Q11.2 deletion
1/25.000
Angelman Syndrome
15q11.2 deletion
1/10.000 – 1/20.000
1p36 deletion Syndrome
1p36 deletion
1/5.000 – 1/10.000
Wolf-Hirschhorn Syndrome
4p deletion
1/50.000
PrenatalSafe® Plus is not indicated for dichorionic twin pregnancies.
PrenatalSafe® Plus can be integrated, for free, with RhSafe® test, a non-invasive prenatal exam that, analyzing the fetal DNA isolated from a blood sample of the mother to be, allows to determine fetal Rh(D) Factor. RhSafe® test is optional, and is performed for free (on request) in Rh(D) negative pregnant women, with a Rh(D) positive male partner.
