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PaternitySafe® – Non invasive prenatal paternity test (Legal Use)

PaternitySafe® is an advanced non-invasive prenatal paternity testing for determining fatherhood.
Non-Invasive Prenatal Paternity Testing can be used to assess the paternity before the child is born.
PaternitySafe® allows to profile the baby’s DNA through the analysis of cell-free fetal DNA found in the mother’s blood, and subsequently to compare the baby’s profile to the one of the alleged father.

The test is performed by taking a blood sample from the mother with a gestational age of at least 9 weeks. Thanks to a complex laboratory analysis, cell-free DNA is isolated from maternal plasma and then sequenced using Next Generation Sequencing (NGS) techniques. The baby’s genetic profile is made up of half of the genetic profile from the mother and half from the father. Therefore, the alleged father, to be considered the biological father, will have to own half of the genetic profile present in the baby. Paternity is EXCLUDED in case in which the genetic characteristics of the putative father differ from those of the baby, while it is ATTRIBUTED if they match.
The method used by the laboratory to verify paternity is the same for both information and legal testing. The difference concerns the method of collecting the samples and their identification. In fact, for a test to be legally valid it is necessary that a third and independent person, such as a doctor or a biologist, verify and ascertain the origin of the samples. 


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